Lucie Vondráčková comes from a musical family. Her father Jiří Vondráček is a musician, while her mother, Hana Sorrosa Vondráčková, is a respected lyricist. She speaks five languages and has Ecuadorian roots via a maternal grandfather.
Vondráčková attended primary school in Prague. She studied music and drama at the Prague Conservatory, and completed the course of Cultural studies, with a Master of Arts degree.[citation needed] She earned the degree of Doctor of Philosophy in 2006 at Charles University in Prague.
On 17 June 2011, she married Czech International hockey player Tomáš Plekanec who played for the Montreal Canadiens and Toronto Maple Leafs in the National Hockey League. The couple has 2 sons, Matyáš and Adam.